The Emmy Noether-funded research group of Dr. Dr. med. Alexander Busch investigates the regulation of the hypothalamic-pituitary-gonadal (HPG) axis—a key system in human reproductive development and fertility. The group combines clinical cohorts, population-scale genetics, and molecular biology to understand how early life periods, such as minipuberty and puberty, shape reproductive capacity.
The position is embedded in the IMF-funded project “ANDROGEN”, which aims to functionally validate newly identified genetic variants that regulate quantitative spermatogenesis. This integrative project combines GWAS, bulk and single-cell transcriptomics, protein validation, and regulatory reporter assays.
Learn more about the group here.
YOUR MISSION:
- Investigate how genetic variants affect male reproductive function
- Perform single-nucleus and bulk RNA sequencing of testicular tissue
- Validate gene expression at the protein level via IHC and Western blotting
- Analyze large-scale transcriptomic data (R, Python)
- Test allele-specific regulatory activity using luciferase reporter assays
- Integrate omics data to identify functional variants affecting spermatogenesis
Table of Content
Summary
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Benefits
- A full 3-year PhD position within a dynamic Emmy Noether group
- A central role in a cutting-edge multi-omics project with direct translational relevance
- Individual mentoring, conference participation, and career development support
- A collaborative, international, and family-friendly work environment
Requirements
- A Master’s degree in Biology, Molecular Medicine, Biochemistry, Biotechnology, or a related discipline
- Solid wet-lab experience in molecular biology, ideally with tissue or protein work
- Motivation to develop bioinformatics and data analysis skills (training provided)
- Proficiency in English (spoken and written); German is a plus but not required
- Team spirit, communication skills, and scientific curiosity
- Prior experience with transcriptomics and/or reproductive biology
Application Documents
- A motivation letter describing your interest in reproductive biology and genomics
- A brief summary of your laboratory and/or analytical experience
- Your CV
- Names and contact details of 1–2 referees willing to provide a letter of reference
Application Deadline
August 27, 2025How To Apply
Are you qualified and interested in this opportunity? Kindly go to
University of Münster on p78quickapply-r3jdhzllus.dispatcher.eu2.hana.ondemand.com to apply
For inquiries, please contact: Dr. Dr. med. Alexander S. Busch, [email protected]
For more information, kindly visit University of Münster scholarship webpage.
