The focus of this collaborative project is to identify essential components of the thiol metabolism in the human malaria parasite Plasmodium falciparum.
Using state-of-the-art CRISPR-Cas9 genome editing and biochemical methods, you will:
- Systematically generate and analyze inducible knockout parasite lines
- Assess the essentiality of central enzymes of the thiol redox metabolism
- Characterize non-lethal knockout cell lines through confocal microscopy and biochemical assays.
While genes from lethal knockout attempts will be considered for future intervention strategies, interesting phenotypes of non-lethal knockout cell lines will provide crucial insights regarding the relevance of the parasite's thiol metabolism for the synthesis of DNA or iron-sulfur clusters as well as the conversion and detoxification of redox metabolites.
Table of Content
Summary
- Application DeadlineNovember 15, 2025
- Study LevelPhD
- SponsorRPTU University of Kaiserslautern-Landau
- City to studyRhineland-Palatinate
- School to studyRPTU University of Kaiserslautern-Landau
- Eligible CountryAll Countries
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Benefits
- Health promotion
- Family Service Center
- Vocational Training
- Flexible working hour
- Jobticket
- Retirement provision
- Sport & Fitness programms
- Culture & Leisure offers
- Local recreation in the Palatinate Forest
Requirements
- A scientific completed university degree in science in molecular/cellular biology or biochemistry
- Fluency in written and spoken English and/or German
- Strong enthusiasm for hands-on laboratory work
- Ability to work independently and in a team
- A passion for solving scientific puzzles and applying critical thinking
Application Deadline
November 15, 2025How To Apply
Are you qualified and interested in this opportunity? Kindly go to
RPTU University of Kaiserslautern-Landau on jobs.rptu.de to apply
For more information, kindly visit RPTU scholarship webpage.
