The focus of this collaborative project is to identify essential components of the thiol metabolism in the human malaria parasite Plasmodium falciparum.
Using state-of-the-art CRISPR-Cas9 genome editing and biochemical methods, you will:
- Systematically generate and analyze inducible knockout parasite lines
- Assess the essentiality of central enzymes of the thiol redox metabolism
- Characterize non-lethal knockout cell lines through confocal microscopy and biochemical assays.
While genes from lethal knockout attempts will be considered for future intervention strategies, interesting phenotypes of non-lethal knockout cell lines will provide crucial insights regarding the relevance of the parasite's thiol metabolism for the synthesis of DNA or iron-sulfur clusters as well as the conversion and detoxification of redox metabolites.
Table of Content
Summary
- Application DeadlineNovember 15, 2025
- Study LevelPhD
- SponsorRPTU University of Kaiserslautern-Landau
- City to studyRhineland-Palatinate
- School to studyRPTU University of Kaiserslautern-Landau
- Eligible CountryAll Countries
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Benefits
- Health promotion
- Family Service Center
- Vocational Training
- Flexible working hour
- Jobticket
- Retirement provision
- Sport & Fitness programms
- Culture & Leisure offers
- Local recreation in the Palatinate Forest
Requirements
- A scientific completed university degree in science in molecular/cellular biology or biochemistry
- Fluency in written and spoken English and/or German
- Strong enthusiasm for hands-on laboratory work
- Ability to work independently and in a team
- A passion for solving scientific puzzles and applying critical thinking
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Application Deadline
November 15, 2025How To Apply
Are you qualified and interested in this opportunity? Kindly go to
RPTU University of Kaiserslautern-Landau on jobs.rptu.de to apply
For more information, kindly visit RPTU scholarship webpage.
